HEPS Achieves Performance Enhancement in Accelerator Stability for Synchrotron Radiation
Recently, the High Energy Photon Source (HEPS) achieved stable light delivery at 100 mA. Beam emittance is the core metric for evaluating accelerator performance; the smaller the emittance value, the higher the beam quality. Following further performance optimization, emittance testing conducted earlier this year measured 44 picometer-radians at 100 mA beam current, placing HEPS among the world’s leading facilities. Additionally, the HEPS commissioning team successfully commissioned and deployed critical control loops including fast orbit feedback, main radiofrequency frequency feedback, and high-frequency synchronous phase feedback, controlling electron beam position fluctuations at the light source point to below 1 micrometer during 100 mA high-current operation, with continuous fault-free light delivery reaching 76 hours. These advances will strongly support user trial experiments and lay a solid foundation for HEPS formal operations.
Source: Institute of High Energy Physics, Chinese Academy of Sciences
NBIC Contributes to Development of Super-Broadband Time-Domain Stimulated Raman Scattering (SuperB-SRS) Technology
Recently, a research team led by XIONG Hanqing from the College of Future Technology at Peking University and the National Biomedical Imaging Center (NBIC), in collaboration with Peking University Third Hospital (PUTH), developed Super-Broadband Time-Domain Stimulated Raman Scattering technology utilizing the Multimode Trans-Scale Biomedical Imaging Facilities. This technology achieves super-broadband Raman spectra comparable to top-tier spontaneous Raman scattering spectroscopy, with imaging speeds 100 times faster than conventional confocal Raman spectrometers, and inherently supports simultaneous multicolor two-photon fluorescence detection for high-resolution imaging of various biological tissues. Through high-throughput serum spectral data acquisition, the team extracted 11 core biochemical indicators assessing liver and kidney function, cardiovascular disease, and other physiological states from approximately 2,600 clinical serum samples, providing high-quality big datasets for AI and big data-driven health science. The research has been published in Nature Photonics.
Source: National Biomedical Imaging Center, Peking University
Meridian Project Data Advances Research on Equatorial Plasma Bubbles and Neutral Winds
Recently, doctoral student ZHANG Aibin, Researcher ZHU Yajun, and collaborators from the State Key Laboratory of Solar Activity and Space Weather at the National Space Science Center, Chinese Academy of Sciences, utilized 1.5 years of observational data from the dual-channel optical interferometer and all-sky airglow imager constructed under the Meridian Project (Ground-based Space Environment Monitoring Network). They retrieved thermospheric neutral wind parameters at 250 km altitude and Equatorial Plasma Bubble (EPB) drift parameters. EPBs significantly affect radio signals and remain a hot topic in ionospheric physics research. This study statistically analyzed the correlation between EPB zonal drift and zonal neutral winds. Results indicate that over 50% of EPBs move at the same velocity as zonal neutral winds, demonstrating complete activation of the F-region dynamo. The research has been published in JGR: Space Physics.
Source: National Space Science Center, Chinese Academy of Sciences
Stem Cell Institute Develops Novel NKP Tumor Therapy Technology Overcoming Traditional CAR-NK Cell Persistence Bottlenecks
Recently, a research team led by WANG Jinyong from the Institute of Zoology, Chinese Academy of Sciences at the Beijing Institute for Stem Cell and Regenerative Medicine developed a pluripotent stem cell-induced CAR-iNK progenitor (CAR-iNKP) cell therapy. This approach enables large-scale in vivo production of long-lasting CAR-iNK cells, allowing effective clearance of minimal residual disease in human B-ALL and T-ALL tumor animal models through combination with traditional chemotherapy requiring only low-dose, single-dose CAR-iNKP cell infusion, significantly reducing tumor recurrence rates. This research provides a novel technical solution to the challenges of short in vivo persistence and insufficient long-term efficacy faced by traditional CAR-NK cell therapy. The findings have been published in Cell Stem Cell.
Source: Beijing Institute for Stem Cell and Regenerative Medicine
UCAS and Collaborators Achieve New Progress in Heart Failure Treatment Mechanism Research
Recently, Professor LU Zhongbing from the College of Life Sciences at the University of Chinese Academy of Sciences (UCAS) and collaborators achieved new progress in heart failure treatment mechanism research. SERCA2a is a key protein regulating cardiomyocyte calcium homeostasis, and its decreased expression is an important driver of heart failure development. While 4E-binding proteins (4E-BPs) serve as critical eukaryotic translation initiation inhibitors, their role in regulating myocardial SERCA2a expression and pressure overload-induced heart failure remains unclear. To address this, the research team constructed 4E-BP1/2 double-knockout mouse models, combined with aortic constriction-induced heart failure animal models, and elucidated for the first time that 4E-BPs regulate SERCA2a expression at the translational level and mediate mitochondrial redox signaling to improve heart failure, providing a novel potential therapeutic target for clinical heart failure treatment. The research has been published in Redox Biology.
Source: University of Chinese Academy of Sciences (UCAS)